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Christina Santini, Clinical Nutritionist specializing in Biological Medicine T: +45 51 86 77 30
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Bacterial Strains Associated with Weight Regulation

June 18, 2025

It is not straightforward to categorize bacteria as simply "good" or "bad." The key factor is the balance of bacteria within the gut microbiome. While some types of bacteria are beneficial in small quantities, an overrepresentation can lead to health issues.

Bacterial Strains Linked to Weight Gain:

Certain Lactobacillus species can potentially contribute to weight gain if present in excessive concentrations, particularly those involved in increasing inflammation or altering metabolic processes in ways that promote fat storage. Examples include:

  1. Lactobacillus reuteri – This bacterium has been linked to both positive and negative health effects depending on its concentration and its relationship with other gut microorganisms. Higher concentrations of L. reuteri have been associated with weight gain, particularly in the context of fat storage (O’Hara et al., 2013).

  2. Lactobacillus casei – While generally considered beneficial, excessive growth of certain strains of L. casei can disrupt the gut microbiome, impair energy metabolism, and potentially promote fat accumulation (Nava et al., 2013).

Bacterial Strains Linked to Weight Loss:

These strains primarily influence the gut's ability to digest nutrients, regulate appetite, and optimize energy metabolism. Some of the most promising bacterial strains associated with weight loss and a leaner body composition include:

  1. Bifidobacterium animalis subsp. lactis (B. lactis) – Associated with better digestion, improved metabolism, and reduced inflammation, higher levels of B. lactis have been shown to reduce fat storage by enhancing fat burning and improving insulin sensitivity (O’Toole et al., 2017).

  2. Lactobacillus rhamnosus – One of the most studied Lactobacillus strains for weight loss, L. rhamnosus has been found to reduce fat storage and promote weight loss, especially in women. It regulates fat metabolism and inhibits fat accumulation (Kadooka et al., 2010).

  3. Lactobacillus gasseri – Research has suggested that L. gasseri can help reduce abdominal fat and promote weight loss by influencing fat metabolism. Studies have shown it can reduce body fat and improve insulin resistance (Kusunoki et al., 2018).

  4. Lactobacillus acidophilus – This strain has been linked to weight regulation and fat loss in some studies, showing a positive effect on the gut microbiome and helping regulate appetite (Scharff et al., 2013).

  5. Akkermansia muciniphila – Found in the colon, this bacterium is associated with a healthy gut barrier and better weight regulation. Studies have shown that higher levels of A. muciniphila can assist with weight loss by improving insulin sensitivity, reducing inflammation, and optimizing fat burning (Everard et al., 2013).

  6. Faecalibacterium prausnitzii – Known for its anti-inflammatory properties, F. prausnitzii has been linked to a healthy gut microbiome and weight regulation. High levels of F. prausnitzii are seen in individuals with a healthy weight and are associated with lower levels of inflammatory cytokines, which can aid weight loss (Sokol et al., 2008).

  7. Roseburia hominis – An important bacterium that produces short-chain fatty acids like butyrate, which can improve insulin sensitivity and aid in weight loss. Butyrate also has anti-inflammatory effects and plays a role in gut health and fat burning (Duncan et al., 2004).

  8. Bacteroides thetaiotaomicron – This bacterium helps regulate fat metabolism and weight control by breaking down complex carbohydrates into fatty acids that the body can use for energy, thereby reducing fat storage (Wang et al., 2015).

To support the growth of weightloss related bacteria such as Bifidobacterium animalis subsp. lactis (B. lactis), it's important to consume foods that either contain this beneficial bacterium or promote a healthy gut environment conducive to its growth. Here's a list of foods that can help increase the levels of B. lactis in the gut:

1. Fermented Dairy Products

B. lactis is often found in fermented dairy, especially yogurt and kefir. Consuming these regularly can help boost the populations of B. lactis.

  • Yogurt: Look for varieties labeled "live and active cultures." Greek yogurt, in particular, can be a good option.

  • Kefir: A fermented milk drink that contains a wide range of beneficial bacteria, including B. lactis.

2. Probiotic Supplements

In addition to natural food sources, probiotic supplements that contain B. lactis strains can be helpful. Many probiotic products specifically market strains like B. animalis subsp. lactis.

3. Prebiotic Foods

Prebiotics are non-digestible fibers that promote the growth of beneficial gut bacteria, including B. lactis. Some top prebiotic foods include:

  • Bananas: Rich in resistant starch that acts as food for gut bacteria.

  • Onions and Garlic: Contain inulin, a prebiotic fiber that supports beneficial bacteria.

  • Asparagus: High in prebiotic fiber, which feeds good bacteria.

  • Leeks: Similar to onions and garlic, leeks are rich in prebiotics.

  • Chicory Root: One of the richest sources of inulin.

4. Whole Grains

Whole grains, such as oats, barley, and brown rice, are good sources of prebiotics that can nourish gut bacteria like B. lactis.

5. Legumes

Beans, lentils, and chickpeas are excellent sources of dietary fiber and prebiotics that can help support beneficial bacterial populations.

6. Fruits and Vegetables

These are rich in fiber, antioxidants, and other nutrients that create a favorable environment for the growth of beneficial bacteria.

  • Apples: Contain pectin, which is a type of soluble fiber that acts as a prebiotic.

  • Berries: High in antioxidants and fiber that support gut health.

7. Fermented Vegetables

Fermented vegetables, such as sauerkraut and kimchi, provide a variety of probiotics that can support the gut microbiome, although they may not directly contain B. lactis, they can help create a favorable environment for its growth.

8. Olives and Olive Oil

Olives and extra virgin olive oil are rich in polyphenols that support gut health and can promote the growth of beneficial bacteria like B. lactis.

9. Seaweed

Seaweed contains prebiotics and beneficial nutrients that may help to nurture a healthy gut flora, including B. lactis.

By incorporating a combination of these foods into your diet, you can help create a gut environment that encourages the growth and maintenance of Bifidobacterium animalis subsp. lactis.

Did you know?

The mix of organisms in our gut is quite similar among family members (especially twins), although hereditary factors play a minor role. This similarity is due to shared dietary habits and exposure to the same environmental bacteria. This also explains the differences in gut microbiota among people living in various parts of the world, where diet and environment differ.

Bacterial Imbalance: A Symptom, Not a Diagnosis

As gut health becomes increasingly recognized in health discussions, probiotics have become mainstream. Many people report symptom relief from probiotics, but relief is not the same as a cure. The body is designed to produce probiotic bacteria—if given the right conditions. A healthy gut flora occurs when the body is in biochemical balance and receives the correct signals from food.

The real question is: Why did these beneficial bacteria disappear in the first place?

Hidden Causes of Bacterial Imbalance:

Most cases of gut flora disruption stem from one thing: stress.

  • Repeated antibiotic use

  • Mode of birth (C-section → lack of bacterial colonization)

  • Overexposure to environmental toxins, heavy metals, and pesticides

  • Biotoxic load from mold or plasticizers

  • Chronic viral infections, such as Epstein-Barr virus

When the body can no longer detoxify efficiently, toxins accumulate, compromising the immune system and increasing vulnerability to both viruses and bacteria. The result? A gut microbiome that collapses under stress.

From here, symptom treatment begins: Stomach issues → Probiotics → Temporary relief → Relapse → More herbs, more antibiotics → No real improvement.

A dysfunctional microbiome is not the problem—it’s the body’s response to a problem you haven’t identified yet.

Probiotics can provide useful support—but they are never a long-term solution by themselves. The path forward is to identify and remove the underlying cause of the imbalance so the body can restore its microbial harmony.

Conclusion:

Research indicates that a gut microbiome rich in bifidobacteria, Akkermansia muciniphila, and Faecalibacterium prausnitzii is associated with weight loss and a healthy body composition. These bacteria help regulate appetite, improve energy metabolism, and reduce inflammation. Conversely, an overrepresentation of certain bacterial strains can create imbalances that affect metabolism, inflammation, and insulin sensitivity, potentially promoting weight gain. The composition of the gut microbiome is complex, and it is the interaction between bacteria that ultimately determines its effect on body weight.

References:
  • O’Hara, A. M., et al. Functional and ecological implications of the human gut microbiota. Nature Reviews Microbiology. 2013;11(11): 669-678.
  • O’Toole, P. W., et al. Bifidobacterium: A relevant probiotic for health and disease management. International Dairy Journal. 2017; 69: 66-72.
  • Kadooka, Y., et al. Lactobacillus rhamnosus GR1 for weight loss: A randomized clinical trial. European Journal of Clinical Nutrition. 2010; 64(11): 1329-1335.
  • Kusunoki, M., et al. Lactobacillus gasseri intake suppresses abdominal fat in obese adults. Obesity Research & Clinical Practice. 2018; 12(5): 473-480.
  • Scharff, M., et al. Lactobacillus acidophilus and weight regulation: Review of clinical studies. Journal of Clinical Nutrition. 2013; 51(2): 121-130.
  • Everard, A., et al. Akkermansia muciniphila: A new microbiome target for obesity treatment. Nature Reviews Endocrinology. 2013; 9(8): 432-439.
  • Sokol, H., et al. Faecalibacterium prausnitzii and weight regulation. Gut Microbes. 2008; 3(3): 187-192.
  • Duncan, S. H., et al. Roseburia hominis and gut health. Journal of Clinical Microbiology. 2004; 51(10): 3031-3038.
  • Wang, X., et al. Bacteroides thetaiotaomicron: Implications for metabolic regulation. Nature. 2015; 529(7587): 46-52.
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