I am not a big fan of synthetic supplements - and there are plenty of studies supporting that synthetic vitamins are NOT comparable to natural vitamins due to missing co-factors amongst other issues.

Synthetic vitamin C is however what most of us are consuming if we are taking supplements on the regular. And I only recommend synthetic vitamin C if you are acutely fighting an infection as the longterm benefits are severely lacking - on the contrary.

A recent study reported a positive association between supplemental vitamin C intake and kidney stones in a cohort of 23,355 Swedish men; the multivariable adjusted relative risk associated with supplemental use of vitamin C was almost double compared with no use!

Read the full study here: https://pubmed.ncbi.nlm.nih.gov/23381591/

NOTE: I absolutely do recommend supplements, but the quality most of us are taking is absolute garbage and not related to better health outcome. The headlines in the newspapers do not differentiate between synthetic supplements and naturally derived supplements, although this is the key issue in the health outcome!